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CVE-2025-12921— OpenClinica Community Edition CRF Data Import ImportCRFData xml injection

Quick assessment

Affected
OpenClinica Community Edition
Exploitation
No confirmed in-the-wild exploitation; assess based on exposure
Recommended action
Check the vendor advisory and references for a fixed version. If immediate upgrade is impossible, restrict exposure and increase monitoring.

OpenClinica Community Edition是美国OpenClinica公司的一个临床数据管理系统。 OpenClinica Community Edition 3.12.2版本和3.13版本存在安全漏洞，该漏洞源于对文件/ImportCRFData中参数xml_file的错误操作，可能导致XML注入攻击。

CVSS 4.3 · Medium EPSS 0.53% · P43

Possible ATT&CK Techniques 1 AI

T1190 · Exploit Public-Facing Application
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I. Basic Information for CVE-2025-12921

Vulnerability Information
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Vulnerability Title
OpenClinica Community Edition CRF Data Import ImportCRFData xml injection
Source: CVE Program / CVE List V5
Vulnerability Description
A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection. It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.
Source: CVE Program / CVE List V5
CVSS Information
CVSS:3.1/AV:N/AC:L/PR:L/UI:N/S:U/C:L/I:N/A:N
Source: CVE Program / CVE List V5
Vulnerability Type
XML注入(XPath盲注)
Source: CVE Program / CVE List V5
Vulnerability Title
OpenClinica Community Edition 安全漏洞
Source: CNNVD (China National Vulnerability Database)
Vulnerability Description
OpenClinica Community Edition是美国OpenClinica公司的一个临床数据管理系统。 OpenClinica Community Edition 3.12.2版本和3.13版本存在安全漏洞，该漏洞源于对文件/ImportCRFData中参数xml_file的错误操作，可能导致XML注入攻击。
Source: CNNVD (China National Vulnerability Database)
CVSS Information
N/A
Source: CNNVD (China National Vulnerability Database)
Vulnerability Type
N/A
Source: CNNVD (China National Vulnerability Database)

Affected Products

Vendor Product Affected Versions CPE Subscribe
OpenClinica Community Edition 3.0 -

II. Public POCs for CVE-2025-12921

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III. Intelligence Information for CVE-2025-12921

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Proof of Concept for CVE-2025-12921 (1)

News Coverage for CVE-2025-12921 (1)

IV. Related Vulnerabilities

Same product: Community Edition
Same vendor: OpenClinica
Same weakness: CWE-91

V. Comments for CVE-2025-12921

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